Short Course Radiotherapy

Inclusion Criteria:

* Male or female, aged 21 years or below
* Lansky performance status \>= 40
* Has a diagnosis of an incurable malignancy that:

  * Originates outside the brain but is metastatic to 1 or more sites within the brain, or originates and recurs within the brain. For this diagnosis to be confirmed, there must be multidisciplinary review of up to date imaging at a pediatric tumor board with unanimous consensus of intracranial relapse or metastasis. If the consensus is not unanimous, short-interval repeat imaging with subsequent unanimous consensus would be required in order for this eligibility criteria to be met
  * Has at least 1 targetable intracranial lesion as seen on imaging
  * Has a multidisciplinary consensus recommendation for palliative intent radiation
* Consents to the study or has caregiver who is able to provide signed and dated informed consent. For subjects under the age of 18, a signed and dated assent form as able.
* Patients who had prior radiation in planned treatment area are also eligible to enter the trial
* Stated willingness to comply with all study procedures and availability for the duration of the study

Exclusion Criteria:

* Radiotherapy for curative intent
* Serious uncontrolled systemic or psychiatric disorders that would interfere with participation in the protocol
* Being planned for proton radiation