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Advancing Strategies to Optimize the PerIopeRativE Management of PostOperative Nausea and Vomiting (ASPIRE-PONV) Trial

Who can join

Ages 18 and older · All sexes

Adult Inclusion Criteria

* Age ≥ 18 years
* Planned surgery with general anesthesia with endotracheal intubation or laryngeal mask airway
* Meet zero or more risk factors for PONV ( history of motion sickness or postoperative nausea and vomiting, non-smoker, female sex, duration of inhalation anesthesia greater than 1 hour, undergoing high risk surgical procedure (cholecystectomy, laparoscopy, gynecologic), and perioperative opioid use)

Adult Exclusion Criteria

* ASA 6 including organ procurement,
* Patients anticipated to be transferred directly to the intensive care unit intubated,
* Procedure types:

  * Electroconvulsive therapy,
  * Intubation only cases,
  * labor epidurals,
  * transesophageal echocardiography (TEE)/cardioversion,
  * surgery duration \< 30 minutes.

Operating Room Anaesthesia Provider Inclusion Criteria

Any operating room anaesthesia provider of eligible patients will be included.

About the study

The goal of this prospective, unblinded, pragmatic and repeated crossover trial is to learn if clinical decision support alerts will impact postoperative nausea and vomiting (PONV) prophylaxis and reduce PONV rates in adult patients who have planned surgery with general anesthesia. The main aim is to improve PONV, establishing a scalable Clinical Decision Support (CDS) Tool for personalized PONV prevention.

The primary hypothesis is that, compared with standard care, the Anesthesia Workflow-Driven Clinical Decision Support Tool for Personalized PONV Prevention will be associated with a significant improvement in the rate of appropriate administration of PONV prophylaxis and a significant decrease in the incidence of PONV.

This study will evaluate a new clinical decision support (CDS) tool designed to improve how and when PONV prevention strategies are used. Unlike traditional tools that provide generic, one-time alerts, this new system is integrated into the electronic health record (EHR) and delivers timely, targeted reminders to anesthesia providers at key moments during a patient's surgical care-such as before surgery begins, after anesthesia is given, and before the patient wakes up. These alerts are based on each patient's individual risk for PONV and are intended to support, not replace, clinical judgment. The study will use a crossover design over 12 months, alternating between periods when the tool is active and when it is not. The goal is to determine whether this time-sensitive, workflow-integrated tool can lead to better adherence to best practices and improved patient outcomes.

What is being tested

• AW-D Clinical Decision Support Tool (other)

Sponsor: Vanderbilt University Medical Center · Participants: 19,480 · Started: Sep 3, 2025

Contact the study team

• Miklos Kertai, M.D., Ph.D. · Phone: 615-875-0378
• Gail Mayo · Phone: 615-936-1705

Official record on ClinicalTrials.gov — NCT07152249

Locations in the U.S.

Conditions

• Postoperative Nausea and Vomiting

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.