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Genicular Nerve Block for Knee Pain in the ED

Ultrasound-Guided Genicular Nerve Block for Knee Pain in the Emergency Department: A Randomized Controlled Trial

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* Atraumatic knee pain
* \>17 years age
* X-ray of the knee obtained in the ED
* Initial pain score (numeric rating scale) 5-10

Exclusion Criteria:

* Fracture or dislocation on x-ray
* large knee joint effusion identified on x-ray
* allergy or contraindication to local anesthetics
* History of local anesthetic systemic toxicity after receiving local anesthetics
* Pregnancy
* Incarcerated
* History of knee replacement of affected knee
* Concern for septic joint
* Overlying cellulitis
* Hemodynamic instability
* Altered mental status or inability to consent for procedure.

About the study

Patient with atraumatic knee pain without a large knee effusion on x-ray will be randomized to receive either a genicular nerve block (GNB) or standard of care in the emergency department.

What is being tested

• Genicular nerve block with bupivacaine and corticosteroids (procedure)
• Standard of Care (other)

Sponsor: University of Pennsylvania · Participants: 34 · Started: Aug 6, 2025

Contact the study team

• Umar Clinical Research Coordinator, AB · Phone: 267-624-4394

Official record on ClinicalTrials.gov — NCT07158736

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.