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SBU-RESET: RElaxation, Stress Reduction and Epigenetics Trial in Cancer Survivors

Pilot Study of a Social/Behavioral Intervention on Cancer Survivors, Evaluating the Effect of Mind Body Interventions on Patient Reported Outcomes, Inflammation and Epigenetics.

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* Adults over 18 years old
* Primary diagnosis: Lung Cancer, Colon Cancer and Non-Hodgkin's lymphoma (NHL)
* Six months post cancer-directed treatment (chemotherapy, targeted and immunotherapy). Patients with active disease (e.g. metastatic colorectal cancer) who are not receiving any cancer-directed treatment are eligible.
* Able to provide a saliva sample
* Gives informed consent and agrees to be randomly assigned
* Able to complete the questionnaire(s) in English.

Exclusion Criteria:

* Adults with primary anal and/or primary rectal cancer.
* Adult cancer survivors who are currently on an active treatment regimen.
* Oral or any pathological conditions that can limit the ability to produce saliva.
* Unable to participate in full length study period and follow up thereafter.
* Is pregnant or plan to become pregnant during the study period.
* Currently practicing yoga or SMART
* Those on corticosteroid therapy.
* Documented fall or syncope within the last 6 months

About the study

Cancer survivors can experience health issues that cause chronic illness and lower quality of life. Yoga is a well-known holistic approach to health and overall well-being. Mindfulness has many benefits, including improved focus and less stress. This study aims to evaluate if yoga and/or mindfulness has a positive effect on cancer survivors social, emotional and physical well-being as well as their epigenetics. Epigenetics is how the environment can effect your genes; not by changing our DNA, but by turning genes on or off.

What is being tested

• Oncology-informed yoga (behavioral)
• SMART (behavioral)

Sponsor: Barbara Nemesure · Participants: 100 · Started: Sep 17, 2025

Contact the study team

• Stony Brook Cancer Center Clinical Trials · Phone: 631-728-7425
• Chitra Thakur, PhD · Phone: (631)-216-9086

Official record on ClinicalTrials.gov — NCT07161713

Locations in the U.S.

Conditions

• Cancer (all types)

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.