Home › Community-Acquired Pneumonia › NCT07164131
Azithromycin Versus Doxycycline in Hospitalized Adult Patients With Community Acquired Pneumonia Treated With Beta-lactams
RecruitingPhase 4
Who can join
Ages 18 and older · All sexes
Full eligibility criteria
Inclusion Criteria: • All adult patients (\>18 years old) admitted with CAP and receiving a beta-lactam antibiotic plus a form of atypical coverage (azithromycin or doxycycline) in the ED within 12 hours of admission. Exclusion Criteria: * High clinical suspicion for Legionella pneumonia * Allergy or contraindication to the use of either azithromycin or doxycycline (usual clinical practice) * Antibiotics not for CAP * Pregnant women (based on clinical assessment as part of standard of care) * Severe CAP as defined by the ATS/IDSA criteria * Corrected QT prolongation (\> 450 ms in men and \> 460 ms in women) * Incarcerated individuals (prisoner)
About the study
The purpose of this study is to compare effectiveness and safety of Azithromycin versus Doxycycline in adult patients hospitalized with community acquired pneumonia (CAP) treated with Beta-lactams.
What is being tested
- Doxycycline (drug)
- Azithromycin (drug)
Sponsor: Mayo Clinic · Participants: 1,120 · Started: Sep 15, 2025
Contact the study team
- Amy Amsbaugh, RRT · Phone: 5075387538
- Aysun Tekin, MD, MS · Phone: 5072661273
Official record on ClinicalTrials.gov — NCT07164131
Locations in the U.S.
| Arizona | Mayo Clinic in Arizona, Scottsdale (Not yet recruiting) |
| Florida | Mayo Clinic in Florida, Jacksonville (Not yet recruiting) |
| Minnesota | Mayo Clinic Health System-Mankato, Mankato (Not yet recruiting) Mayo Clinic in Rochester, Rochester |
| Wisconsin | Mayo Clinic Health System-La Crosse, La Crosse (Not yet recruiting) |
Conditions
From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.