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Effect of Product Characteristics on the Abuse Liability of Nicotine Pouches

Who can join

Ages 21 to 35 · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* Current established users of nicotine pouches (have used nicotine pouches in the past 30 days \& currently use nicotine pouches every day or someday)
* Positive cotinine test via saliva test strip
* Those who are unmotivated to quit nicotine use
* Read and speak English.
* Poly-users of nicotine pouches, e-cigarettes (e.g., vape ≥20 days/month), and tobacco (e.g., ≥4 cigarettes/day for ≥2 years) will be eligible for participation

Exclusion Criteria

* Planning to cut down or quit using nicotine in the next 30 days
* Currently pregnant or breastfeeding
* History of stroke, seizures, high blood pressure, heart disease/problems, or cardiovascular disease contraindications for nicotine.

About the study

The goal of this study is to assess the effects of nicotine concentration and its interplay with pH on sensory experience, product appeal, and abuse liability of NPs among young adults NP users.

Primary objective is to assess the effect of variation in nicotine concentration in nicotine pouches (NPs) and its interaction effect with pH level on three proximal outcomes of relevance to regulation: (1) sensory experience, (2) product appeal, and (3) abuse liability of NPs.

What is being tested

• Nicotine pouch: Low dose (other)
• Nicotine pouch: High dose (other)
• Low pH (other)
• High pH (other)

Sponsor: Emory University · Participants: 84 · Started: Feb 13, 2026

Contact the study team

• Dae Hee Han, PhD · Phone: 404-727-8742

Official record on ClinicalTrials.gov — NCT07165808

Locations in the U.S.

Conditions

• Quitting Smoking (Tobacco Use Disorder)

From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.