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Low Level Light Therapy & Skin Pigmentation

Recruiting

Who can join

Ages 18 and older · All sexes

Full eligibility criteria
Inclusion Criteria:

* Ability to read and understand the study informed consent in English
* Age 18 years or older at enrollment
* Individuals with MGD based on one or more of the following clinical signs/symptoms, e.g., meibum quality score of 1-3 (Bron et al.), meibography score of 1, 2, or 3 on the Pult Meiboscale, non-invasive 1st tear break up time of 10 seconds or less, or an Ocular Surface Disease Index (OSDI) score greater than 12 points.

Exclusion Criteria:

* Active anterior segment pathology (e.g., bacterial conjunctivitis, microbial keratitis)
* History of systemic disease associated with aqueous-deficient dry eye disease (e.g., Sjogren's syndrome)
* History of corneal surgery, refractive surgery, or eyelid surgery within 6 months
* History of corneal ectasia (e.g. keratoconus, Pellucid marginal degeneration)
* History of ocular trauma within 6 months
* History of LipiFlow, iLux, Meiboflow, IPL or LLLT within the last 12 months
* Habitual use of photosensitizing medications within the last 30 days
* Pregnant and/or lactating females, by self-report
* Pigmented lesions, tattoos, or skin cancer in the periocular region
* Unwilling to have eyes photographed or video recorded

About the study

The goal of this clinical trial is to determine if there is a difference in eyelid temperature after low-level light therapy (LLLT) in individuals with different amounts of skin pigmentation and dry eye/meibomian gland disease. Participants will have 3 fifteen minute in office LLLT therapy sessions over a period of approximately 7 to 14 days.

What is being tested

Sponsor: University of Houston · Participants: 40 · Started: Jun 11, 2025

Contact the study team

Official record on ClinicalTrials.gov — NCT07173530

Locations in the U.S.

TexasThe University of Houston College of Optometry, Houston

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.