An External Control Arm Study in Non-Small Cell Lung Cancer

Inclusion Criteria:

1. \> 18 years of age at the time of informed consent
2. Pathologically confirmed locally advanced or metastatic NSCLC
3. ECOG Performance of less than or equal to 1 within 4 weeks prior to starting index therapy.
4. Life expectancy of more than 3 months
5. Able to understand and sign informed consent
6. Evidence of measurable disease (as assessed by the Investigator) on available imaging (e.g CT, MRI, PET)

\*see protocol for cohort specific inclusion criteria\*

Exclusion Criteria:

1. Actively on a clinical trial of an investigational agent
2. Currently receiving active systemic therapy for another malignancy
3. Eligible for treatment with curative intent

\*see protocol for cohort specific exclusion criteria\*