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Resilience Enhancement Using Electronic Frailty Index-Directed Care Pathway

Recruiting

Resilience Enhancement Utilizing an Electronic Frailty Index-Directed Care Pathway for Older Adults Receiving Chemotherapy (RESILIENCE-e): A Prospective Single-Arm Interventional Study

Who can join

Ages 65 and older · All sexes

Full eligibility criteria
Inclusion Criteria:

Patients with cancer:

* Ability to understand and willingness to sign an IRB-approved informed consent
* Age ≥ 65 years at the time of enrollment.
* Planned to initiate an outpatient chemotherapy regimen (including myelosuppressive biologic/immune therapies) for cancer treatment (any type or stage), either as an initial therapy or as a new line of therapy, with curative or palliative intent.
* eFI pre-frail or frail status (available in EHR; defined as eFI \> 0.10) within 30 days before enrollment.
* Ability to read and understand the English language

Providers:

* Treating medical oncologist of at least one patient participant who enrolled on to the study and completed baseline assessment.

Exclusion Criteria:

Patients:

* Documented physical or psychological comorbidity that would limit participant's ability to understand or comply with study procedures for the entire length of the study per the enrolling investigator.
* Chemotherapy planned at a facility outside the Atrium Health system.
* Currently receiving chemotherapy (defined as planned to continue an on-going treatment rather than starting a new regimen).

About the study

The study purpose is to gain a better understanding of the needs of adults aged 65 and older while they are receiving chemotherapy by measuring their resilience and tailor care plans based on their individual needs.

What is being tested

Sponsor: Wake Forest University Health Sciences · Participants: 32 · Started: Mar 16, 2026

Contact the study team

Official record on ClinicalTrials.gov — NCT07175376

Locations in the U.S.

North CarolinaLevine Cancer Institute, Charlotte
Atrium Health Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.