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A Study of SCAD Using Stress Contrast Echocardiography

Myocardial Perfusion in Spontaneous Coronary Artery Dissection Using Stress Contrast Echocardiography

Who can join

Ages 18 and older · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* Adult \>18 years old
* Patient has a history of spontaneous coronary artery dissection (SCAD) OR patient is healthy with no significant medical history

Exclusion Criteria:

* Unable to give consent
* Allergic or have a history of adverse reaction to dobutamine, the Definity® ultrasound enhancing agent, or atropine.
* Has a known or suspected hypersensitivity to perflutren and therefore cannot be given Definity®.
* Pregnant.
* Unable to interrupt breastfeeding.
* Within 3 months of a heart attack.
* Severe aortic stenosis.
* Severe, uncontrolled hypertension (\>200/110 mmHg at baseline).

About the study

This study aims to fill knowledge gaps regarding microvascular perfusion and pressor response to stress among patients with history of spontaneous coronary artery dissection (SCAD) using stress contrast echocardiography.

What is being tested

• Stress Echocardiography with Contrast (procedure)

Sponsor: Mayo Clinic · Participants: 50 · Started: Nov 25, 2025

Contact the study team

• Pamela Engrav · Phone: 507-255-6938

Official record on ClinicalTrials.gov — NCT07178509

Locations in the U.S.

Conditions

• Spontaneous Coronary Artery Dissection

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.