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Menstrual Cycle TMS Plasticity Pilot
Pilot Study on Menstrual Cycle-Related Hormonal Effects on Motor Cortex Plasticity Assessed by TMS in Healthy Young Adults
Who can join
Ages 20 to 40 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Able to give their consent * If female, must have menstrual cycles of normal frequency, regularity, and duration. Exclusion Criteria: * Non-English speaking * Any medical condition that increases risk for TMS * History of seizure * History of epilepsy * Increased risk of seizure for any reason
About the study
Aim 1: Assess how menstrual cycle phase affects motor cortex plasticity in females.
Aim 2: Compare motor cortex plasticity between males and females across the same time points, identifying potential sex differences in TMS response.
Aim 3: Examine associations between serum hormone levels and TMS-induced plasticity within and between sexes.
What is being tested
- transcranial magnetic stimulation (device)
Sponsor: University of Pennsylvania · Participants: 100 · Started: Dec 15, 2025
Contact the study team
- Nicholas Balderston, PhD · Phone: 12157463058
Official record on ClinicalTrials.gov — NCT07180654
Locations in the U.S.
| Pennsylvania | University of Pennsylvania, Philadelphia |
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.