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Determinants of Cardiorespiratory Fitness and Effects of HIIT in Patients With ANOCA Obstructive Coronary Artery Disease(ANOCA)
Determinants of Cardiorespiratory Fitness and Effects of High Intensity Interval Training (HIIT) in Patients With Angina and No Obstructive Coronary Artery Disease (ANOCA)
Who can join
Ages 18 to 85 · All sexes
Full eligibility criteria
Inclusion Criteria: * Age 18-85 * ANOCA (Anginal symptoms of chest pain or exertional dyspnea suspected to be from myocardial ischemia Invasive or CT coronary angiogram without obstructive epicardial CAD (≥50% left main or ≥70% other epicardial stenosis or fractional flow reserve ≤0.80) * Able to use the wearable and participate in a remote exercise program * Able to participate in intermittent high-intensity training. * Able to perform cardiopulmonary exercise testing (CPET) * Able to provide Health-related quality of life questionnaire (HRQOL) * Participants must be able to understand and provide informed consent in English and complete the study questionnaire in English Exclusion Criteria: * Systolic heart failure (LVEF \<50% or NYHA class III symptoms) * Prior myocardial infarction, coronary revascularization * Inability to safely undergo cardiopulmonary exercise testing, based on investigator's judgment * Pregnancy (due to unknown effects on CPET exercise markers) * Inability to provide informed consent * Life expectancy \<1 year * Prisoners * Cognitively impaired * Non-English speaking
About the study
The main goal is to understand what causes reduced fitness in ANOCA and whether targeted exercise can help improve it.
This study aims to better understand why patients with Angina and No Obstructive Coronary Artery Disease (ANOCA) have poor cardiorespiratory fitness and its effect on quality of life.
Investigators also want to see if a structured high-intensity exercise program (HIIT), done with remote monitoring, can safely improve heart function, fitness, and quality of life in these patients. The Investigators will use a special exercise test called cardiopulmonary exercise testing to look for patterns that can help explain exercise limitations and quality of life in ANOCA before and after a remote high-intensity exercise program.
What is being tested
- EXERCISE TRAINING WITH OR WITHOUT MEDICATION (behavioral)
Sponsor: University of Virginia · Participants: 25 · Started: Aug 11, 2025
Contact the study team
- Rahel Askari · Phone: 434-243-7195
Official record on ClinicalTrials.gov — NCT07182955
Locations in the U.S.
| Virginia | University of Virginia Health System, Charlottesville |
Conditions
From ClinicalTrials.gov, data retrieved Oct 3, 2026. Each study sets its own eligibility; the study team decides who can join.