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CMT Gait, Mobility, Balance - AOFAS Grant
Lower Extremity Gait, Mobility and Balance Confidence in Charcot-Marie-Tooth Patients With Cavovarus Foot Deformity
Who can join
Ages 25 to 55 · All sexes
Full eligibility criteria
Inclusion Criteria: 1) Clinical diagnosis and genetic confirmation of CMT, 2) Between the ages of 12 and 75, 3) Able to walk at a slow to moderate pace without an AFO, 3) Able to read and write in English and provide written informed consent. 4) Individuals in the NonOP group must have an AFO prescribed for daily activities. Individuals in the OP group will also have had 5) surgical correction of CMT cavovarus foot deformity focused on muscle balancing and hindfoot correction. Exclusion Criteria: 1) Other causes or risk factors for peripheral neuropathy (for example diabetes, ETOH abuse), 2) Uncorrected visual impairment, 3) History of musculoskeletal injury requiring surgery 4) loss of plantar protective sensation 5) Pain \>4/10 while walking (or an increase in pain during testing of \>2/10), 6) Concern by the examiner that the individual will not complete the study. For the NonOP group 7) Previous surgical correction of CMT cavovarus foot deformity focused on muscle balancing and hindfoot correction
About the study
The overall objective of the proposed research is to begin to better understand the potential benefits and limitations of ankle -foot orthosis (AFO) use in the context of mobility and balance during gait for individuals with Charcot-Marie-Tooth disease (CMT). These benefits will be studied in comparison to those offered by surgical correction. We will accomplish by having subjects undergo mobility and balance tests in our gait analysis lab.
What is being tested
- Ankle-foot Orthoses (device)
Sponsor: Bopha Chrea · Participants: 66 · Started: Aug 14, 2025
Contact the study team
- Bopha Chrea, MD · Phone: 319-356-3943
- Lauren Crowe, BS · Phone: 319-467-7128
Official record on ClinicalTrials.gov — NCT07188415
Locations in the U.S.
| Iowa | University of Iowa Medical Campus - North Liberty (MCNL), North Liberty |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.