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To Compare Post-Extraction Use of a Novel Ethylenediaminetetraacetic Acid (EDTA) Post-operative Mouth Rinse and Daily Use EDTA Mouth Rinse and Standard 0.12% Chlorhexidine (CHX) Post-operative Mouth Rinse and Daily Use Essential Oil (EO) Mouth Rinse.

A Prospective, Randomized Clinical Trial to Compare Post-extraction Use of a Novel Ethylenediaminetetraacetic Acid (EDTA) Post-operative Mouth Rinse and Daily Use EDTA Mouth Rinse and Standard 0.12% Chlorhexidine (CHX) Post-operative Mouth Rinse and Daily Use Essential Oil (EO) Mouth Rinse.

Who can join

Ages 18 to 85 · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* Able to read and provide informed consent in English
* At least 18 years old
* Established and registered patient of the UAB School of Dentistry
* Patients presenting with one single rooted tooth determined to need extraction and simultaneous ridge preservation bone grafting for future dental implant placement.
* Presence of periodontally healthy, non-carious neighboring teeth and/or healthy restored dental implants on either side of the tooth planned for extraction.
* No anticipated need for surgical and/or endodontic care at teeth adjacent to the proposed surgical site during the study period.

Exclusion Criteria:

* Non-English speaking
* Age less than 18 years old or older than 85 years old
* Smokers/nicotine users (\>10 cigarettes or equivalent/day)
* Patients with systemic pathologies or conditions contraindicating oral surgical procedures or adversely affecting wound healing
* Multiple adjacent teeth require extraction and grafting
* Absence of adjacent teeth/implants on either side of the tooth to be extracted.
* Documented or suspected allergy or sensitivity to any study product

About the study

This study will compare commercially available, commonly used mouth rinses (0.12% chlorhexidine (CHX) vs. Ethylenediaminetetraacetic acid (EDTA)) for immediate post-operative and daily antiseptic use after tooth extraction and ridge preservation grafting followed by daily use of commercially available an essential oil (EO) mouthrinse and EDTA mouthrinse.

What is being tested

• 0.12% CHX and Essential Oil mouthrinse (other)
• 2.6% EDTA and 0.2% EDTA mouth rinse (other)

Sponsor: University of Alabama at Birmingham · Participants: 40 · Started: Mar 2, 2026

Contact the study team

• Maria L Geisinger, DDS, MS · Phone: 205-934-4984
• Sarah Jane Startley, DMD · Phone: 205-975-8711

Official record on ClinicalTrials.gov — NCT07191262

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.