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PKU Protein Requirements

Defining Protein Requirements in Adults With PKU: Impact of Genotype and Medical Food Intake

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* will be males and females (50:50) 18 years and older who were diagnosed with PKU through newborn screening or diagnosis later in life, capable of providing consent, and have previously had mutation testing

Exclusion Criteria:

* include concurrent illness, recent history of weight loss or acute illness during the past 6 months that could affect protein metabolism, pregnancy, lack of regular menstruation, implantable electronic devices or pacemakers, history of claustrophobia, and inability to provide consent. In addition, participants will be excluded if their genotype subgroup has already reached its predefined maximum enrollment (n=4)

About the study

The objective of this research is to determine the protein requirements based on genotype and medical food consumption in a sample of adults with Phenylketonuria (PKU) using the indicator amino acid oxidation (IAAO) method.

What is being tested

• Nonradioactive stable oral isotope (other)
• Test diet (other)

Sponsor: Emory University · Participants: 18 · Started: Feb 16, 2026

Contact the study team

• Jessica Strosahl, PhD, RDN, LD · Phone: 404-727-1528

Official record on ClinicalTrials.gov — NCT07194993

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.