A Study to Evaluate INCA036873 in Participants With Advanced Solid Tumors and Hematological Malignancies

Inclusion Criteria:

* Age ≥18 years.
* ECOG performance status of 0 or 1.
* Histologically confirmed:

  * Clear cell renal cell carcinoma (ccRCC).
  * Diffuse large B-cell lymphoma (DLBCL, NOS).
  * High-grade B-cell lymphoma (HGBCL).
  * Peripheral T-cell lymphoma (PTCL, incl. NOS and ALCL).
  * Cutaneous T-cell lymphoma (CTCL, incl. MF or SS ≥Stage IIB with B0/B1 blood involvement).
* Disease progression, relapse, or refractory to prior therapy:

  * ccRCC: ≥1 prior line incl. ICI + TKI.
  * DLBCL/HGBCL: ≥2 prior lines incl. immunochemotherapy and salvage.
  * PTCL/CTCL: ≥1 prior systemic therapy.
* Measurable disease by RECIST v1.1 (ccRCC), Lugano 2014 (lymphomas), or ISCL/USCLC/EORTC (CTCL).
* Tumor tissue available for central testing.

Exclusion Criteria:

* Untreated or progressive CNS disease unless previously treated and stable.
* Other active invasive malignancy within 2 years (except certain low-risk cancers).
* Prior CD70-targeting therapy, including CAR T.
* ASCT or CAR T ≤12 weeks before enrollment; prior organ or allogeneic transplant.
* Unresolved ≥Grade 2 toxicity from prior therapy (with exceptions).
* Primary immunodeficiency or active autoimmune disease requiring immunosuppression.
* Active HBV, HCV, HIV, or other chronic infections requiring systemic therapy.
* Pregnancy, breastfeeding, or unwillingness to use effective contraception.

Other protocol-defined Inclusion/Exclusion Criteria may apply.