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Evaluation of a Neural-Controlled Powered Prosthesis Across Diverse Real-World Tasks

Who can join

Ages 18 to 70 · All sexes

Inclusion Criteria:

* Male or Female age 18-70.
* The patient must have a unilateral transfemoral amputation .
* The patient must have the ability to ambulate at variable cadence (an expected lower extremity prosthesis functional level of K3 or above).
* The patient must have adequate socket to support the device.

Exclusion Criteria:

* Women who are pregnant.
* Severe co morbidity, atypical skeletal anatomy, or poor general physical/mental health that, in the opinion of the Investigator, will not allow the subject to be a good study candidate (i.e. other disease processes, mental capacity, substance abuse, shortened life expectancy, vulnerable patient population, BMI \>40, etc.).

About the study

The purpose of this study is to evaluate the performance and adaptability of a neural-controlled powered knee or ankle prosthesis across diverse real-world mobility tasks. This research aims to assess how compare the sense of embodiment with the device, symmetry, and stability of a person with an lower-extremity amputation walking with a bionic prosthesis and their prescribed prosthesis. Findings from this study will inform future developments in bionic prosthesis design with optimal integration with the human body, with the goal of improving prosthetic integration into daily life.

What is being tested

• MIT Powered Leg (device)

Sponsor: Massachusetts Institute of Technology · Participants: 10 · Started: May 31, 2025

Contact the study team

• John A McCullough, B.S. Mechanical Engineering · Phone: 424-603-1074

Official record on ClinicalTrials.gov — NCT07204912

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.