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A Digital Intervention to Decrease Self-Stigma Among Pregnant and Postpartum Women With Substance Use Disorder

Who can join

Ages 18 and older · Women

Inclusion Criteria:

* Pregnant women and new mothers (up to 12 months postpartum)
* Adult (≥18 years of age)
* Fluent in English
* Currently owns or has ready (daily) access to a smartphone or tablet to use Enhearten.
* Self-reports a history of substance use, excluding alcohol use, nicotine/tobacco use, and drugs taken as prescribed by a physician OR a history of substance use, excluding alcohol use, nicotine/tobacco use, and drugs taken as prescribed by a physician, is identified in chart review as documented by a healthcare provider

Exclusion Criteria:

\- Significant cognitive impairment that interferes with their ability to consent and complete study tasks as self-reported or documented in medical charts by a healthcare provider

About the study

Digital interventions have the potential to support healthier behaviors among pregnant and postpartum women (PPW) with substance use disorders (SUDs) and may also provide a promising method for reducing their self-stigma. Enhearten is a digital intervention designed to foster adherence to medications for addiction treatment (MAT) while considering the unique needs of PPW, but its effects on self-stigma, treatment retention, and SUD outcomes have not been rigorously tested. The investigators will conduct an individual-level multicenter randomized controlled trial to test the feasibility, acceptability, and efficacy of Enhearten on reducing self-stigma and on improving SUD treatment and recovery outcomes with a stigma-focused ecological momentary intervention (EMI) designed to: 1) screen for feelings of stigma and 2) counteract these vulnerabilities among PPW with SUD via just-in-time interventions.

What is being tested

• Enhearten with EMI (behavioral)
• Waitlist Control Group (behavioral)

Sponsor: Washington University School of Medicine · Participants: 152 · Started: Nov 24, 2025

Contact the study team

• Alex T Ramsey, Ph.D. · Phone: 314-362-5370
• Elecia Worley, MSW · Phone: 314-362-9004

Official record on ClinicalTrials.gov — NCT07211867

Locations in the U.S.

Conditions

• Drug Use and Addiction

From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.