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Pharmacokinetics, Safety, and Efficacy of Povorcitinib in Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa

RecruitingPhase 2

A Phase 2, Open-Label Study to Evaluate the Safety, Pharmacokinetics, and Efficacy of Povorcitinib in Adolescents With Moderate to Severe Hidradenitis Suppurativa

Who can join

Ages 12 to 17 · All sexes

Full eligibility criteria
Inclusion Criteria:

* Aged ≥ 12 to \< 18 years at the time of informed consent/assent signing.
* Body weight ≥ 30 kg at both screening and baseline visits.
* Diagnosis of moderate to severe HS for at least 3 months prior to the screening visit.
* Total abscess and inflammatory nodule count of at least 5 at both the screening and baseline visits.
* HS lesions corresponding to refined Hurley Stage IB, IC, IIB, IIC, or III at both the screening and baseline visits.
* Documented history of inadequate response to at least a 3-month course of at least 1 conventional systemic therapy (oral antibiotic or biologic drug) for HS (or demonstrated intolerance to, or have a contraindication to, a conventional systemic therapy for treatment of their HS).
* Agreement to use contraception.
* Willing and able to comply with the study protocol and procedures.
* Further inclusion criteria apply.

Exclusion Criteria:

* Presence of \> 20 draining tunnels (fistulas) at either the screening or baseline visit.
* Women who are pregnant (or who are considering pregnancy) or breastfeeding.
* Medical history including thrombocytopenia, coagulopathy or platelet dysfunction, Q-wave interval abnormalities, current or history of certain infections, cancer, lymphoproliferative disorders and other medical conditions at the discretion of the investigator.
* Laboratory values outside of the protocol-defined ranges.
* Further exclusion criteria apply.

About the study

The purpose of this study is to evaluate the pharmacokinetics, safety, and efficacy of povorcitinib in adolescent participants with moderate to severe hidradenitis suppurativa over a 54-week open-label treatment period.

What is being tested

Sponsor: Incyte Corporation · Participants: 40 · Started: Feb 2, 2026

Contact the study team

Official record on ClinicalTrials.gov — NCT07213973

Locations in the U.S.

AlabamaUniversity of Alabama At Birmingham, Birmingham
ArizonaMedical Dermatology Specialists Phoenix, Phoenix
Saguaro Dermatology, Phoenix
ConnecticutUconn Health, Farmington
FloridaSkin Research of South Florida, Llc, Miami
University of Miami Miller School of Medicine, Miami
Trueblue Clinical Research, Tampa
GeorgiaAdvanced Medical Research Pc, Sandy Springs
IllinoisEndeavor Health Medical Group, Skokie
KansasDermatology Skin Cancer Center Leawood, Leawood
KentuckyEquity Medical, Bowling Green
MarylandJohns Hopkins Univ Schl of Medicine, Baltimore
Skin Oasis Dermatology, Gambrills (Not yet recruiting)
MassachusettsBoston Childrens Hospital, Boston
MichiganOakland Hills Dermatology Pc, Auburn Hills
Wayne State University Physician Group Dermatology, Detroit
Revival Research Institute, Llc Troy, Troy
MissouriUniversity of Missouri Kansas City, Kansas City (Not yet recruiting)
Washington University, St Louis
MontanaBoeson Research Missoula 2825 Fort Missoula Rd, Missoula
New MexicoUniversity of New Mexico Hospital, Albuquerque
PennsylvaniaGeisinger Medical Center, Danville
TexasBellaire Dermatology Associates Bda, Bellaire
Texas Dermatology Research Center, Dallas
3A Research Llc West Location, El Paso (Not yet recruiting)
UtahJordan Valley Dermatology Center, South Jordan

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.