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Follicular Fluid microRNAs in Ovarian Aging and Reproduction

Investigating the Role of Follicular Fluid microRNAs in Ovarian Aging and Assisted Reproductive Success

Who can join

Ages 18 and older · Women

Inclusion Criteria:

* Women undergoing IVF treatment due to male factor infertility or nonovarian causes.
* Age groups: younger women \<31 years and older women \>38 years.
* Regular menstrual cycles.
* Willing and able to provide informed consent.

Exclusion Criteria:

* Minors (under 18 years) and women aged 32-37 years
* Diagnosis of polycystic ovarian syndrome (PCOS).
* History of recurrent pregnancy loss.
* Presence of endometriosis.
* Diagnosis of ovarian insufficiency.
* Metabolic disorders (e.g., diabetes).
* History of ovarian surgery or chemotherapy.
* Any condition that might impact follicular fluid quality or IVF outcomes.

About the study

The purpose of this study is to investigate the role of exosomal microRNAs (miRNAs) in follicular fluid (FF) as biomarkers of ovarian aging and predictors of in vitro fertilization (IVF) outcomes. The goal is to identify noninvasive molecular markers that correlate with oocyte quality and reproductive potential, particularly in women of advanced maternal age.

What is being tested

• No Interventions (other)

Sponsor: University of Central Florida · Participants: 100 · Started: Sep 22, 2025

Contact the study team

• Amoy Fraser, PhD, CCRP, PMP · Phone: 4072668742
• Britney-Ann Wray, BS, CTBS, CCRP · Phone: 4072668742

Official record on ClinicalTrials.gov — NCT07214246

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.