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A Study to Assess the Adverse Events and How Oral Emraclidine Moves Through the Body of Healthy Elderly Adult Participants

RecruitingPhase 1Healthy volunteers welcome

A Phase 1, Randomized, Placebo-controlled Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Emraclidine Following Multiple Ascending Oral Doses in Healthy Elderly Subjects

Who can join

Ages 65 to 85 · All sexes · Healthy volunteers welcome

Full eligibility criteria
Inclusion Criteria:

* BMI is ≥ 18.0 to ≤ 32.0 kg/m2 after rounding to the tenths decimal at Screening. BMI is calculated as weight in kg divided by the square of height measured in meters.
* Body weight \> 45 kg at the time of screening and upon initial confinement.
* A condition of general good health, based upon the results of a medical history, physical examination, vital signs, laboratory profile and a 12-lead ECG.

Exclusion Criteria:

* History of any clinically significant cardiac, respiratory (except mild asthma as a child), renal, hepatic, gastrointestinal, genitourinary, immunological, hematologic, neurological or psychiatric disease or disorder, or any other uncontrolled medical illness.
* History of any clinically significant sensitivity or allergy to any medication or food.
* Evidence of dysplasia or history of malignancy (including lymphoma and leukemia) other than successfully treated non-metastatic cutaneous squamous cell, basal cell carcinoma or localized carcinoma in situ of the cervix.

About the study

This study is to assess how oral emraclidine moves through the body of healthy elderly adult participants, and assess adverse events, and tolerability.

What is being tested

Sponsor: AbbVie · Participants: 52 · Started: Oct 8, 2025

Contact the study team

Official record on ClinicalTrials.gov — NCT07219030

Locations in the U.S.

FloridaK2 Medical Research, LLC /ID# 276636, Maitland
Clinical Pharmacology Of Miami /ID# 276856, Miami
IllinoisAcpru /Id# 276996, Grayslake
New JerseyHassman Research Institute Marlton Site /ID# 276876, Marlton

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.