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Effects of a 5-Week Probiotic Supplementation Intervention on Markers of Delayed Onset Muscle Soreness

Who can join

Ages 18 to 30 · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* complete a minimum of 150 minutes a week of at least moderate intensity exercise in either an endurance-based or resistance-based training style based on a self-reported physical activity over the past month
* good general health with no injuries or health conditions that would affect physical activity
* willing to abstain from consistent NSAID use and other probiotic supplements over the course of this study

Exclusion Criteria:

* known musculoskeletal injuries or physical limitations that could interfere with performing the designated physical activity required
* underlying conditions that could place them at an increased risk during exercise such as cardiovascular, respiratory, or metabolic diseases
* currently take a probiotic supplement, are prescribed and taking an antibiotic during the intervention, or report using NSAIDs or steroids within the recovery time window
* report using an NSAID more than twice a week on a regular basis

About the study

The purpose of this study is to evaluate how probiotic supplementation (PS) influences post-exercise recovery in healthy, physically active young adults. Researchers aim to determine if the Lactobacillus casei probiotic strain reduces symptoms of delayed onset muscle soreness (DOMS) based on perceived muscle soreness, pressure pain threshold, and power output following exercise induced muscle damage (EIMD).

What is being tested

• Lactobacillus casei (dietary supplement)
• Placebo Capsule(s) (other)

Sponsor: University of Minnesota · Participants: 24 · Started: Feb 5, 2026

Contact the study team

• Jakob Fischer · Phone: 507-236-8051

Official record on ClinicalTrials.gov — NCT07219498

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.