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Handgrip Training and Brain Blood Flow Regulation

Who can join

Ages 18 to 35 · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* 18 to 35 years old
* Body mass index ≤30 kg/m2 (without obesity)
* Physically inactive (not meeting the current recommendations of ≥150 minutes per week of moderate-to-vigorous aerobic exercise and not ≥2 days per week of resistance training) in last 6 months
* Have a smartphone and are willing to download mobile applications used in this project

Exclusion Criteria:

* Having an overt chronic condition (e.g., cardiovascular, cerebrovascular, etc.)
* Being pregnant, planning to become pregnant, or breastfeeding/lactating
* Regular use of nicotine products in the past 6 months
* Recent head injury/trauma or concussion

About the study

This study aims to investigate the effect of isometric handgrip training on brain blood vessel function in physically inactive adults. Isometric handgrip training is a promising strategy for lowering blood pressure and improving vascular health, but no previous investigations have studied the effect of training on markers of brain blood vessel function. Based on previous work showing improvements in vascular function after isometric handgrip training, we hypothesize that isometric handgrip training will improve key markers of cerebrovascular function.

What is being tested

• Handgrip Training (device)

Sponsor: Florida State University · Participants: 40 · Started: Oct 27, 2025

Contact the study team

Official record on ClinicalTrials.gov — NCT07223645

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.