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Impact of Intraoperative Oxygenation Practices on Patient Outcomes

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* Patient located in a participating operating room
* Planned surgery includes tracheal intubation

Exclusion Criteria:

* Patient is known to be less than 18 years old
* Patient is known to be pregnant
* Patient is known to be a prisoner.
* Patient is American Society of Anesthesiologists (ASA) classification-6 (i.e., organ donor)
* Patient's planned surgical case includes open heart surgery, defined as surgery on the heart or ascending aorta requiring sternotomy or thoracotomy.
* Patient's planned procedure requires prolonged apnea, bronchoscopy, airway surgery, or one-lung ventilation.
* Patient's planned surgical case includes use of extracorporeal membrane oxygenation (ECMO).
* Patient is known to have a history of bleomycin treatment.
* Patient was enrolled in the trial in the prior 30 days.

About the study

This multicenter, cluster-randomized, cluster-crossover clinical trial evaluates the impact of three intraoperative FiO2 (Fraction of Inspired Oxygen) oxygenation strategies-lower (FiO₂ 0.21-0.40), intermediate (FiO₂ 0.40-0.80), and higher (FiO₂ 0.80-1.00)-on postoperative organ injury and mortality in adult surgical patients. The trial aims to determine the optimal oxygenation strategy to improve perioperative outcomes.

What is being tested

• Lower FiO2 (other)
• Intermediate FiO2 (other)
• Higher FiO2 (other)

Sponsor: Frederic T Billings IV · Participants: 54,000 · Started: Dec 1, 2025

Contact the study team

• Tracie Baker, CCRA · Phone: 6158751852

Official record on ClinicalTrials.gov — NCT07224243

Locations in the U.S.

Conditions

• Acute Kidney Injury
• Stroke

From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.