Recovery of Physical Function After Critical Illness In Older Adults
RETURN: Recovery of Physical Function After Critical Illness In Older Adults
Who can join
Ages 18 to 99 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * adult patients (≥40 years of age) * patients who have survived an ICU admission of at least 72 hours * diagnosis of acute lung injury or sepsis are eligible. Exclusion Criteria: * individuals who were not ambulatory prior to ICU admission, * not expected to survive at least 6 months, * have a new or pre-existing brain infarct, injury, or neurological condition with deficits preventing participation in physical testing, * have a pre-existing geriatric syndrome that were confound recovery trajectory
About the study
The proposed study is a prospective, observational study assessing the recovery of muscle and physical function in patients surviving critical illness (n =150) at hospital discharge (baseline) and repeated serially. Patients will be enrolled after life-saving modalities have been weaned near hospital discharge. Patients will participate in testing at baseline, 3-, 6-, 12-, and 24-months after hospital discharge. In a subset of patients (n = 18), muscle biopsies will be performed at baseline and then repeated once at either 12- or 24-months after hospital discharge.
Sponsor: University of Kentucky · Participants: 150 · Started: Mar 11, 2026
Contact the study team
- Doug Long, MS · Phone: 859-218-0596
- Kirby P Mayer, DPT, Ph.D. · Phone: 859-218-0596
Official record on ClinicalTrials.gov — NCT07225257
Locations in the U.S.
| Kentucky | University of Kentucky, Lexington, Kentucky 40536, Lexington |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.