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Hormonal Optimization: Late vs. Immediate Start After Discontinuation of Oral Contraceptives in Assisted Reproductive technologY (HOLIDAY)

A Randomized Blinded Controlled Trial Assessing Hormonal Optimization: Late vs. Immediate Start After Discontinuation of Oral Contraceptives in Assisted Reproductive technologY (HOLIDAY)

Who can join

Ages 18 to 40 · Women

Inclusion Criteria:

1. Ovary-bearing individuals 18 to 40 years of age.
2. BMI \< 40 kg/m2
3. Non-smoker for at least 3 months prior to study enrollment.

Exclusion Criteria:

1. BMI greater than or equal to 40 kg/m2
2. Current Smoker
3. Any contraindications to ovarian stimulation or outpatient egg retrieval under anesthesia

About the study

HOLIDAY is a two-arm, parallel-group, multi-center, randomized trial in which subjects undergoing planned oocyte cryopreservation will be randomized to receive either a 2-month pause of Combined Hormonal Contraceptives (CHC) or immediate start (without a pause).

What is being tested

• OCP pause (other)

Sponsor: Shady Grove Fertility Reproductive Science Center · Participants: 394 · Started: Feb 25, 2026

Contact the study team

• Tasha Newsome, Clinical Research Supervisor · Phone: 301-545-1289
• Seth J Barishansky, MD · Phone: 475-267-9469

Official record on ClinicalTrials.gov — NCT07225660

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.