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Nanosecond Pulsed Field Ablation in the Management of Benign Thyroid Nodules

RecruitingObservational study

Who can join

Ages 18 and older · All sexes

Full eligibility criteria
Eligibility Criteria

* Scheduled to undergo ultrasound guided nsPFA as standard of care
* Age 18 to 80 years.
* Capable of providing independent consent.
* Presence of biopsy-confirmed benign thyroid nodule , defined as one of the following:

  * Benign FNA X 2 or
  * Benign US guided FNA X 1 + benign thyroid nodule ultrasound appearance (TI-RADS 2) or
  * Benign FNA X 1 and radiographic/laboratory evidence of functional nature
* Nodule measuring \>2cm in greatest dimension
* Presence of compressive symptoms reasonably attributable to thyroid nodule (i.e. pressure sensation, dysphagia, dysphonia, respiratory distress)
* No abnormal cervical lymph nodes during screening visit .

Exclusion Criteria

* Age \<18
* Patients considered unsuitable for nsPFA by the treating physician

About the study

To observe the outcomes of nsPFA therapy to treat benign thyroid nodules.

What is being tested

Sponsor: M.D. Anderson Cancer Center · Participants: 30 · Started: Nov 14, 2025

Contact the study team

Official record on ClinicalTrials.gov — NCT07226804

Locations in the U.S.

TexasMD Anderson Cancer Center, Houston

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.