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Evaluating the Status of Complex Aneuploidy to Locate Additional Transferrable Embryos
ESCALATE: Evaluating the Status of Complex Aneuploidy to Locate Additional Transferrable Embryos
Who can join
All ages · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Having ≥ 1 embryo classified as whole chromosome chaotic or complex aneuploid of 3 or more chromosomes following preimplantation genetic testing for aneuploidy using an NGS based platform Signed informed consent Exclusion Criteria: * Embryos not meeting complex/chaotic criteria Patients declining consent
About the study
This study aims to evaluate the reproductive potential of embryos classified as "complex aneuploid" (involving three or more abnormal chromosomes) or "chaotic" (six or more abnormal chromosomes) through preimplantation genetic testing for aneuploidy (PGT-A). Specifically, we seek to determine whether embryos initially reported as having multiple chromosomal abnormalities might still have the potential for normal chromosomal composition, the opportunity for transfer, and ultimately, the potential to achieve a live birth through re-biopsy and reanalysis.
Key Information:
This portion of the study seeks your consent for the re-biopsy and genetic reanalysis of the embryos only. It does not yet include consent for potential future transfer.
Participation remains completely voluntary, and your decision will not affect your current or future care.
We deeply appreciate your support and commitment to advancing fertility research.
Sponsor: Shady Grove Fertility Reproductive Science Center · Participants: 280 · Started: Nov 1, 2025
Contact the study team
- SGF Research Team SGF Research Team · Phone: (301) 545-1423
Official record on ClinicalTrials.gov — NCT07227116
Locations in the U.S.
From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.