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Open Pilon With FIBERGRAFT AERIDYAN Matrix Bioactive Glass

Acute Bone Grafting of Open Pilon Fractures With FIBERGRAFT AERIDYAN Matrix Bioactive Glass

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* 18 years of age or older
* Open pilon fracture requiring bone grafting
* Able to provide informed consent for the study prior to definitive care

Exclusion Criteria:

* Under 18 years of age
* Open pilon fracture not requiring bone grafting
* Receiving definitive care at an outside facility
* Unlikely to make follow-up appointments
* Active infection at the time of definitive care
* Unable to provide informed consent prior to definitive care
* Prisoners
* Pregnant patients

About the study

Open pilon fractures are challenging problems to manage. Infection rates vary from 6-30% and metaphyseal nonunion varies from 7-20%. The current recommendation for the management of open pilon fractures with bone loss is a staged approach, with internal fixation around an antibiotic spacer. Fibergraft Aeridyan Bone Graft Matrix is currently used along with other forms of allograft at our institution for filling bone voids in open pilon fractures. This is a prospective, observational study looking at the use of Fibergraft Aeridyan bone graft matrix and its efficacy in open pilon fractures. Everything in this study will be according to the standard of care at our institution other than two research only CT scans. One will be performed at the patient's 6-month visit and the other will be performed at the patient's 12-month visit. The investigators hypothesize that Fibergraft Aeridyan Bone Graft Matrix will lead to improved outcomes when compared to standard bone graft for patients by decreasing infection and nonunion rates.

What is being tested

• Fibergraft Aeridyan Matrix (device)

Sponsor: University of Missouri-Columbia · Participants: 45 · Started: Oct 24, 2025

Contact the study team

• Vicki L Jones, MEd · Phone: 573-882-7583
• Nash Kolb · Phone: 573-884-8428

Official record on ClinicalTrials.gov — NCT07227493

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.