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Endothelial Dysfunction After SCI

Endothelial Dysfunction After SCI: Mechanism and Therapeutic Target for SCI-related Cardiovascular Disease

Who can join

Ages 18 and older · All sexes · Healthy volunteers welcome

SCI Inclusion Criteria

* Over age 18 years
* Chronic (\>12 months) SCI
* Motor complete (AIS A/B) SCI
* Paraplegia (neurological level of injury \[NLI\] at T2 or below)

Non-injured Inclusion Criteria

• Over age 18 years

Exclusion Criteria (Both SCI and Non-injured)

* Overt chronic diseases as assessed by: a) clinically documented medical history; b) physical examination; c) blood pressure and ECG at rest; and d) complete blood chemistries and hematological evaluation.
* Active infection
* Recent (\< 3 months) surgery
* Current smoking history (within past 12 months)
* Report more than low-risk alcohol consumption
* History of drug abuse
* Currently taking cardiovascular (statins, beta-blockers) therapeutics and/or other medications that could influence the outcome measures

About the study

This study plans to learn how endothelial cells, single cell lining of blood vessels may be dysfunctional after a spinal cord injury. Endothelial dysfunction will be measured by the capacity of blood vessels to vasodilate (increase in size) and alter blood flow is lower in adults with a spinal cord injury in comparison to adults without a spinal cord injury. The mechanisms which may alter this function may be critical in reducing the risk of heart attacks and strokes in people with spinal cord injuries.

What is being tested

• Intra-arterial Infusion of Vasoactive Agents (procedure)
• Intra-arterial Vitamin C Infusion (procedure)
• Blood Sampling (procedure)

Sponsor: Craig Hospital · Participants: 40 · Started: Jul 31, 2025

Contact the study team

• Genevieve Madera, BS · Phone: 17203454640
• Clare Morey, SLP-CCC · Phone: 303.789. 8621

Official record on ClinicalTrials.gov — NCT07227727

Locations in the U.S.

Conditions

• Spinal Cord Injuries

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.