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Giving Asthmatics Intramuscular Steroids for Preventing Return to the Emergency Department

Giving Asthmatics Intramuscular Steroids for Preventing Return to the Emergency Department: A Randomized Control Trial

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* Adults ≥18 years old presenting to the ED with an asthma exacerbation
* Diagnosed with asthma per International Classification of Diseases, 10th Revision (ICD-10) criteria or by the treating clinician
* Discharged from the ED with a primary diagnosis of asthma exacerbation
* Initiated systemic corticosteroids during the ED visit
* Must be English or Spanish speaking

Exclusion Criteria:

* Current use of systemic corticosteroids, including Emergency Medical Services (EMS) administration before ED arrival
* History of severe adverse reactions to corticosteroids
* Heart failure and uncontrolled diabetes (glucose \>300mg/dL in the ED)
* Pregnancy or breastfeeding as prednisone is the preferred treatment for asthma in this population
* Inability to provide informed consent

About the study

This study aims to compare the efficacy of a one-time IM dose of dexamethasone versus a 5-day course of prednisone in adult ED patients presenting with asthma exacerbations. This is a randomized, controlled, double-blind, non-inferiority trial conducted at two urban EDs within the Montefiore Health System.

What is being tested

• Dexamethasone 16mg IM (drug)
• Prednisone 60mg PO (drug)

Sponsor: Montefiore Medical Center · Participants: 182 · Started: Jul 23, 2026

Contact the study team

• Mustfa Manzur, MD MPH MS · Phone: 718-920-6626

Official record on ClinicalTrials.gov — NCT07228052

Locations in the U.S.

Conditions

• Asthma

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.