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CHEST: A Collaboration With Community HEalth Centers to Implement SmarT for Asthma

RecruitingPhase 4

Who can join

Ages 12 and older · All sexes

Full eligibility criteria
The study population can be viewed from the cluster (clinic), clinician, staff, or patient level.

At the cluster (clinic) level: To be eligible to participate in this study, a cluster (clinic) must meet all the following criteria:

(1) Clinics within participating health systems (Affinia Healthcare and Family Care Health Centers) will be considered eligible if they provided care to ≥100 patients aged ≥12 years with asthma (ICD-10-CM: J45.xx) during the calendar year preceding implementation (2024).

At the clinician level:

Clinicians will be considered eligible if they:

1. are physicians, nurse practitioners, or physician assistants;
2. are actively employed at a participating clinic during the implementation period; and
3. provided care to ≥10 patients aged ≥12 years with asthma (ICD-10-CM: J45.xx) during the 12 months preceding implementation.

At the staff level:

Staff will be considered eligible if they:

1. are actively employed at a participating clinic during the implementation period; and
2. directly support clinical care delivery for patients aged ≥12 years with asthma.

At the patient level:

Patients will be considered eligible if they:

1. are aged ≥12 years;
2. received care at a participating clinic during the implementation period; and (3) meet the study-defined definition of moderate-to-severe asthma based on diagnosis codes, medication use, and/or exacerbation history as defined in the study protocol.

About the study

Purpose: This study aims to improve asthma care by helping clinicians at community health centers prescribe a guideline-recommended treatment called SMART (Single Maintenance and Reliever Therapy).

The investigators will provide training and resources to clinicians, give feedback on prescribing patterns, and offer educational tools for patients and providers. The investigators will roll out these resources in stages across clinics. The study will measure how well the program helps clinicians prescribe SMART therapy and whether it reduces asthma exacerbations in patients.

What is being tested

Sponsor: Washington University School of Medicine · Participants: 2,000 · Started: Jan 6, 2026

Contact the study team

Official record on ClinicalTrials.gov — NCT07241117

Locations in the U.S.

MissouriAffinia healthcare, 1717 Biddle Street, St Louis
Affinia healthcare, 2220 Lemp Ave, St Louis (Not yet recruiting)
Affinia healthcare, 3396 Pershall Road,, St Louis
Affinia healthcare, 4414 North Florissant Avenue, St Louis
Family Care Heath Center, 401 Holly Hills Ave, St Louis (Not yet recruiting)
Family Care Heath Center, 4352 Manchester Ave, St Louis
Washington University in St. Louis School of Medicine, St Louis

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.