Menopausal Hormone Therapy And Left Ventricular Function

Inclusion Criteria

• \>45-60\< years of age

Exclusion Criteria

* Male sex
* Females between STRAW+10 stages -5 and 0
* PMF in STRAW+10 stage +2
* PMF using oral hormone therapy
* Females who entered menopause due to a surgical procedure or in response to pharmacotherapy (e.g., gonadotrophin releasing hormone agonists or chemotherapy)
* Heart disease such as hypertropic cardiomyopathy, congenital abnormalities, chronic heart failure, valve disease, and a history of myocardial infarction
* Medications that impact the central nervous system including selective serotonin reuptake inhibitors, anxiolytics, sedatives, anticholinergic agents, dopamine, amphetamines, or wake-promoting agents (e.g., modafinil). Other medications will be evaluated on an individual basis by the PI.
* Cardiovascular medications is also an exclusion criterion which includes those acting on the renin-angiotensin-aldosterone axis, adrenergic receptor antagonists, diuretics, nitrates, and calcium channel antagonists. Other medications will be evaluated on an individual basis by the PI.
* Pregnancy
* COPD
* Diabetes
* CKD
* Raynaud's phenomenon
* Sleep disorders
* Shift workers
* BMI ≥40.0kg/m2
* Use of nicotine-containing products within the two years preceding study visits
* Active cancer treatment