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GLP1 Fasting Status and Gastric Retention Using Gastric Ultrasound

An Observational Study to Examine Non-inferiority of the Standard ASA Fasting Guidelines Versus 24-hour Clear Liquid Diet for Gastric Volume in Patients Taking GLP-1 Agonists

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* Age 18+
* Have taken a GLP-1 or GLP-GIP agonist medication within the past 30 days
* ASA Physical Classification Status 1-3
* Fall into one of the following groups:

  1. Scheduled elective surgery and meet ASA fasting guidelines (NPO for at least 8 hours prior)
  2. Scheduled elective colonoscopy and have been on a clear liquid diet for at least 24 hours prior

Exclusion Criteria:

* Previous gastric or esophageal surgery
* Abnormal gastric anatomy
* Pregnancy
* Unable to provide written, informed consent
* Non-English speaking

About the study

This study will enroll patients 18 years and older who are taking a GLP-1/GIP medication and 1) are scheduled for elective surgery and meet ASA fasting guidelines (nothing by mouth for at least 8 hours prior), or 2) scheduled elective colonoscopy and have been on a clear liquid diet for at least 24 hours prior. Participants will have a gastric ultrasound prior to surgery to measure any retained gastric contents. The purpose of this study is to determine if people taking GLP-1 receptor agonists and who fast normally are at an equal risk for having retained gastric contents after appropriately fasting for surgery, compared to patients who are on a liquid only diet for 24 hours prior to surgery.

What is being tested

• Gastric Ultrasound (diagnostic test)

Sponsor: Medical University of South Carolina · Participants: 150 · Started: Feb 3, 2026

Contact the study team

• Haley Nitchie, MHA · Phone: 843-792-1869

Official record on ClinicalTrials.gov — NCT07251803

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.