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A Study Comparing JNJ-79635322 and an Anti-B-cell Maturation Antigen (BCMA)xCD3 Bispecific Antibody in Participants With Relapsed or Refractory Multiple Myeloma

RecruitingPhase 3

A Phase 3 Randomized Study Comparing JNJ-79635322 and an Anti-BCMAxCD3 Bispecific Antibody in Participants With Relapsed or Refractory Multiple Myeloma Who Have Received at Least 3 Prior Lines of Therapy Including a PI, an IMiD, and an Anti CD38 Antibody

Who can join

Ages 18 and older · All sexes

Full eligibility criteria
Inclusion:

* Documented diagnosis of multiple myeloma (MM) as defined by the criteria below:

  1. MM diagnosis according to the international myeloma working group (IMWG) diagnostic criteria
  2. Measurable disease at screening as assessed by central laboratory
* Received at least 3 prior lines of antimyeloma therapy including a proteasome inhibitor (PI), an immunomodulatory drug (IMiD), and an anti-cluster of differentiation (CD)38 antibody
* Documented evidence of progressive disease (PD) or failure to achieve a response to the last line of therapy based on investigator's determination of response by IMWG criteria
* Toxicity related to previous anticancer therapy must have resolved to Grade 1 or better
* Have an eastern cooperative oncology group (ECOG) performance status of 0 to 2 at screening and immediately before the start of study treatment administration

Exclusion:

* Active hepatitis of infectious origin
* Known active or prior central nervous system (CNS) involvement or exhibits clinical signs of meningeal involvement of MM
* Suspected or known allergies, hypersensitivity, or intolerance to the excipients of JNJ-79635322 and Teclistamab
* Major surgery, (example, requiring general anesthesia) within 2 weeks before first dose, or will not have fully recovered from surgery, or has surgery planned during the time the participant is expected to participate in the study
* Received or plans to receive any live, attenuated vaccine within 4 weeks before the first dose of study treatment, or during study treatment

About the study

The purpose of this study is to evaluate how well JNJ-79635322 works when compared with an anti-B-cell maturation antigen (BCMA)xCD3 bispecific antibody.

What is being tested

Sponsor: Janssen Research & Development, LLC · Participants: 400 · Started: Feb 4, 2026

Contact the study team

Official record on ClinicalTrials.gov — NCT07258511

Locations in the U.S.

ArizonaMayo Clinic Phoenix, Phoenix
ArkansasUAMS, Little Rock
CaliforniaCity of Hope Duarte, Duarte
City of Hope Orange County Lennar Foundation Cancer Center, Irvine
USC Norris Comprehensive Cancer Center, Los Angeles
University of California San Francisco, San Francisco
ColoradoColorado Blood Cancer Institute, Denver
ConnecticutUniversity of Connecticut Health Center, Farmington
Yale Cancer Center, New Haven
FloridaFlorida Cancer Specialists & Research Institute, Fort Myers
Mayo Clinic Jacksonville, Jacksonville
Moffit Cancer center, Tampa
GeorgiaEmory University, Atlanta
IllinoisCity of Hope Chicago, Zion
IowaUniversity of Iowa Hospital and Clinics, Iowa City
Mission Cancer Blood, Waukee
KansasUniversity of Kansas Cancer Center, Kansas City
KentuckyNorton Cancer Institute, Louisville
MarylandUniversity of Maryland School of Medicine, Baltimore
MassachusettsBoston University Medical Center, Boston
Dana Farber Cancer Institute, Boston
MinnesotaMayo Clinic Rochester, Rochester
New YorkMount Sinai Brooklyn, Brooklyn
NYU Winthrop, Mineola
Icahn School of Medicine at Mount Sinai, New York
Laura and Isaac Perlmutter Cancer Center NYU ACC, New York
Memorial Sloan Kettering Cancer Center, New York
Mount Sinai Chelsea, New York
North CarolinaUniversity of North Carolina, Chapel Hill
Durham VAMC, Durham
OregonOregon Health And Science University, Portland
PennsylvaniaFox Chase Cancer Center, Philadelphia
Thomas Jefferson University Hospital, Philadelphia
TennesseeSCRI Oncology Partners, Nashville
Vanderbilt University Medical Center, Nashville
TexasSt. David's South Austin Medical Center, Austin
Baylor University Medical Center, Dallas
UT Southwestern Medical Center, Dallas
MD Anderson Cancer Center, Houston
Texas Transplant Institute, San Antonio
UtahHuntsman Cancer Institute, Salt Lake City
WisconsinMedical College Of Wisconsin, Milwaukee

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.