Home › Tooth Decay › NCT07265830

Building Adaptive School-based Interventions for Caries

The Building Adaptive School-based Interventions for Caries Study (BASICS): A Phase III Sequential, Multiple-Assignment, Randomized Trial of Minimally Invasive Therapies to Reduce Treatment Nonresponse

Who can join

Ages 5 to 13 · All sexes · Healthy volunteers welcome

Inclusion Criteria:

1. Be enrolled in participating schools
2. Be between the ages of 5 and 13 years
3. Provide parental/guardian informed consent
4. Child assent

Exclusion Criteria:

1. Ulcerative gingivitis or stomatitis
2. Known sensitivity to silver or other heavy-metal ions
3. More than six affected sites
4. Those who have had full mouth gingivectomies
5. Patients showing abnormal skin sensitization in daily circumstances
6. Those who have had pulp capping

About the study

Dental caries (tooth decay) is the world's most prevalent noncommunicable disease. Current preventive and therapeutic treatments are available that can be provided in a school-based health service environment. However, not all children respond to care, and school programs can result in under- or over-treatment, leaving children at high risk. The Building Adaptive School-based Interventions for Caries (BASICS) study will identify the optimal sequence and intensity of these treatments to minimize nonresponse, creating adaptive interventions tailored to specific needs in order to personalize school-based dental medicine.

What is being tested

• Silver Diamine Fluoride (38%) (device)
• Glass Ionomer Sealant (device)
• Fluoride Varnishes (device)
• Hygiene Intervention (behavioral)

Sponsor: University of Pennsylvania · Participants: 1,200 · Started: Aug 18, 2026

Contact the study team

• Ryan R Ruff, PhD, MPH · Phone: 212-998-9663

Official record on ClinicalTrials.gov — NCT07265830

Locations in the U.S.

Conditions

• Tooth Decay

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.