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Frozen Shoulder and Hormone Replacement Therapy

Hormone Replacement Therapy as an Adjunct Treatment for Adhesive Capsulitis of the Shoulder (Frozen Shoulder) in Peri- and Postmenopausal Women

Who can join

Ages 40 and older · Women

Inclusion Criteria:

* Diagnosis of adhesive capsulitis of the shoulder

Exclusion Criteria:

* History of hormone sensitive cancer
* Bilateral adhesive capsulitis of the shoulder
* Currently using hormonal treatments including contraceptives

About the study

The purpose of this study is to determine the effects of hormone replacement therapy (HRT) in addition to standard treatment on frozen shoulder symptoms in women with age-related changes to their menstrual cycle. Frozen shoulder refers to the condition a doctor diagnosed the participant with regarding shoulder pain, stiffness, and progressive loss of range of motion. Age-related menstrual cycle changes, known as perimenopause and/or menopause, refers to a change or stoppage of monthly menstrual cycles. Other symptoms participants may be experiencing include vaginal dryness, hot flashes, or night sweats. Hormone replacement therapy (HRT) refers to medicine with female hormones in it. For this study, HRT will be in the form of a patch that goes on the skin and a daily oral pill. Participants will be randomly assigned to receive either HRT plus standard care, or only standard care. Follow-up tests will be completed at 6 months of treatment to assess participant progress.

What is being tested

• Hormone Replacement Therapy (HRT) (drug)
• Corticosteroid and 1%lidocain (drug)
• physical therapy (behavioral)

Sponsor: University of California, San Francisco · Participants: 60 · Started: Jan 15, 2026

Contact the study team

• Alexa J Chandler, PhD · Phone: (415) 353-2808

Official record on ClinicalTrials.gov — NCT07278323

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.