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Center M Randomized Trial

Who can join

Ages 18 and older · Women · Healthy volunteers welcome

Inclusion Criteria:

* Currently pregnant at ≥ 12 weeks of gestation age (GA)
* ≤ 34 weeks GA at time of Center M intervention initiation
* Receiving prenatal care through the Center for Women's Health at Oregon Health \& Science University
* Able to fluently understand, speak and read English
* Available, able and willing to attend online group sessions
* Willing and able to receive home practice materials on an accessible smartphone, tablet or computer
* Residing in Oregon or Washington
* Willingness to participate in either randomization arm

Exclusion Criteria:

* Current or past enrollment in a formal mindfulness-based intervention group
* Score in the "severe" range on the Edinburgh Postnatal Depression Scale (EPDS) (≥ 20) or Patient History Questionnaire (PHQ-9) (≥ 20)

About the study

This is a randomized controlled trial with an intervention of Center M compared to treatment as usual. Center M consists of weekly digital one-hour group sessions led by a trained therapist aligned with mindfulness based cognitive therapy. Changes in perinatal depression symptoms will be compared between groups.

What is being tested

• Center M (behavioral)

Sponsor: Oregon Health and Science University · Participants: 160 · Started: Jan 15, 2026

Contact the study team

• Ellen Tilden, PhD, CNM, FACNM · Phone: 503-418-2036

Official record on ClinicalTrials.gov — NCT07304895

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.