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Researching Economical Adjuvants to Cancer Therapy

Who can join

Ages 18 to 45 · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* Physically fit enough to engage in maximal exercise.

Exclusion Criteria:

* BMI \> 40 kg/m2
* Stage 2 hypertension (140/90 mmHg)
* Type I or II diabetes
* Autoimmune diseases
* Overt cardiovascular, respiratory, or neurological disease (e.g., previous heart attack, pacemaker, heart failure, asthma)
* Hormone replacement therapy (e.g., androgens, estrogens)
* Daily medication usage that may affect immune function (e.g., beta blockers, NSAIDs, corticosteroids, allergy medications)
* Current antibiotic use
* Heavy alcohol usage (\>2 drinks per day)
* Tobacco use within the last 6 months
* Adults unable to consent
* Individuals who are not yet adults (infants, children, teenagers)
* Self-reported pregnancy
* Prisoners

About the study

The goal of this clinical trial is to learn if beta-glucan (a dietary fiber) improves the function of the immune system in adults. It will also tell the investigators if combining beta-glucan with single bouts of exercise provides additional benefit. The main questions it aims to answer are:

1. Does beta-glucan change the ability of immune cells to recognize cancer cells? 2. Does exercise change the type of immune cells in the blood? Researchers will compare beta-glucan to a placebo (a look-alike substance with no effect) to see if beta-glucan could improve immune function against cancer.

Participants will:

1. Take beta-glucan or a placebo daily for 4 weeks. 2. Visit the laboratory for three exercise tests. 3. Provide blood samples so researchers can study immune system cells.

What is being tested

• Beta-glucan (dietary supplement)
• Placebo (dietary supplement)

Sponsor: Florida State University · Participants: 60 · Started: Nov 12, 2025

Contact the study team

• Kyle A Smith, PhD, RD · Phone: 850-644-1016

Official record on ClinicalTrials.gov — NCT07305259

Locations in the U.S.

Conditions

• Cancer (all types)

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.