A Prospective Longitudinal Observational Cohort Study of Pregnant Women Residing at High Altitude in Bolivia
Who can join
Ages 18 to 45 · Women · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * women delivering at participating hospitals at more than 3500 meters or women delivering at participating hospitals at sea level * signed informed consent Exclusion Criteria: * preexisting cardiopulmonary pathologies (CHD, COPD, CKD, NYHA \> III)
About the study
In this study, the investigators will follow two small cohorts of pregnant women: a cohort of healthy women with uncomplicated pregnancies residing at high altitude, a control group of healthy women with uncomplicated pregnancies residing at sea level, to characterize differences in cardiopulmonary adaptation and nitric oxide (NO) pathway expression at elevations \>3,500 m throughout pregnancy and into the postpartum period. The investigators aim to investigate right-sided cardiac impairment induced by chronic hypobaric hypoxemia, its effects on fetal growth, and the potential contribution of cardiovascular nitric oxide depletion to obstetric complications.
Sponsor: Massachusetts General Hospital · Participants: 27 · Started: Feb 11, 2026
Contact the study team
- Lorenzo Berra, MD · Phone: 617-726-3030
- Andrea Bolchini, MD · Phone: 617-216-5124
Official record on ClinicalTrials.gov — NCT07312227
Locations in the U.S.
| Massachusetts | Massachusetts General Hospital, Boston |
Conditions
From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.