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Antiseptic-Coated Sutures and Pancreatic Fistula Risk After Pancreatoduodenectomy

Does Antiseptic Coated Suture Reduce Pancreatic Fistula Rate After Pancreatoduodenectomy: A Randomized Controlled Trial

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* Subjects must be undergoing a scheduled pancreatoduodenectomy.
* Age ≥18 years.
* Subjects must have the ability to understand and the willingness to sign a written informed consent document

Exclusion Criteria:

* Patients \< 18 years old
* Patients who are pregnant
* Patients with history of previous pancreatic surgery
* Patients who are unable to provide informed consent

About the study

The purpose of this study is to determine if the use of antiseptic-coated sutures is better than the use of the standard sutures in preventing postoperative fistulas within 90 days after pancreatoduodenectomy.

What is being tested

• Standard (non-antiseptic coated) suture will be used. (device)
• Triclosan/antiseptic -coated suture (device)

Sponsor: The Cleveland Clinic · Participants: 436 · Started: Jan 13, 2026

Contact the study team

• Christine Moegling, BS · Phone: 216 399-4706

Official record on ClinicalTrials.gov — NCT07318493

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.