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Assessing MB-Spirit for Psychological Well-being

Assessing MB-Spirit: A Novel Intervention for Promoting Spiritual Development and Psychological Well-being

Who can join

Ages 18 to 50 · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* Understands English
* Able to attend all 8 classes
* Able to travel to Boston for MRI scans

Exclusion Criteria:

* claustrophobia, pregnancy, head trauma, metallic implants or devices contraindicating MRI, left-handed, conditions that alter cerebral blood flow or metabolism (e.g. stroke), current use of psychotropic medications, lifetime history of suicidality, homicidally, self-destructive acts, schizophrenia or psychosis.

About the study

The goal of this clinical trial is to test two new behavioral interventions designed to reduce stress and improve spiritual well-being in stressed adults. The main questions it aims to answer are:

1. Can the program decrease stress and improve spiritual well-being? 2. What brain changes accompany participation in the programs?

Participants will:

1. Be randomized to either a live online course that meets for 90 minutes every week for 8-weeks, or to a self-paced program. In the self-paced program, participants will receive materials once a week and can work through them at their own pace. Both programs are designed to decrease stress and improve well-being. 2. Complete questionnaires before and after the course. 3. Complete and interview before and after the course. 4. A subset of people will be randomized to complete an MRI scan of their brain before and after the course.

Participants will be randomized to either take the course right away, or be put on a wait-list. Those on the wait-list will undergo the testing at 2 timepoints before they start the program.

What is being tested

• MB-Spirit (behavioral)
• Strong Behaviors for Stress Reduction (behavioral)

Sponsor: Sara W Lazar · Participants: 44 · Started: Mar 15, 2026

Contact the study team

• Study Staff · Phone: 617-415-8813

Official record on ClinicalTrials.gov — NCT07325448

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.