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Cold Water Irrigation Therapy as an Adjunct to Indomethacin for Post-Endoscopic Retrograde Cholangiopancreatography(ERCP) Pancreatitis

Adjunctive Cold Water Irrigation Added to Rectal Indomethacin for Prevention of Post- Endoscopic Retrograde Cholangiopancreatography (ERCP) Pancreatitis

Who can join

Ages 20 and older · All sexes

Inclusion Criteria:

* Native papilla present.
* Undergoing ERCP for diagnostic or therapeutic indications.
* Able to provide informed consent.

Exclusion Criteria:

* Post-operative reconstructed intestinal tract other than Billroth I reconstruction.
* Acute pancreatitis at the time of ERCP.
* Chronic pancreatitis.
* Pancreatic head cancer with occlusion of the main pancreatic duct.
* Existing pancreatic duct stent or need for prophylactic pancreatic duct stenting during the index ERCP.
* Known contraindications or allergy to indomethacin or other NSAIDs.
* Significant renal impairment (eGFR \< 30 mL/min/1.73m²).
* Active peptic ulcer disease or history of NSAID-induced gastrointestinal bleeding.

About the study

This study is designed to learn whether rinsing the papilla with cold water at the end of an ERCP procedure, in addition to standard medicine, can help lower the chance of developing pancreatitis, which is the most common major complication after ERCP.

What is being tested

• Cold water (procedure)
• Warm water (procedure)

Sponsor: University of Kansas Medical Center · Participants: 950 · Started: Dec 5, 2025

Contact the study team

• Reza Hejazi · Phone: 913-588-6019
• Roham Salman Roghani · Phone: Salman Roghani

Official record on ClinicalTrials.gov — NCT07330284

Locations in the U.S.

Conditions

• Pancreatitis

From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.