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Emotional Well-being and Measures of Healthy Aging

Emotional Well-being and Biomarkers of Healthy Aging

Who can join

Ages 40 to 70 · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* Age 40-70
* Speaks and reads English
* Able to access the online platform through their phone, a public device (i.e., at the library) or at home.
* Lives in the Chicagoland area
* Willing/able to travel to the Human Longevity Lab for in-person visits

Exclusion Criteria:

* Adults unable to consent
* Individuals who are not yet adults (infants, children, teenagers)
* Pregnant women
* Prisoners
* Vulnerable Populations
* Pre-existing heart disease (prevalent coronary heart and cerebrovascular disease or heart failure)
* Type 2 diabetes
* Severe psychiatric illness

About the study

This randomized control study is designed to understand the role of a positive psychology intervention (PARK: Positive Affect Regulation sKills) in biological aging and well-being. PARK provides a series of positive emotion skills in a self-guided online format, making the program accessible and convenient.

Our main aims are:

Aim 1: To explore the effects of PARK on psychological well-being (e.g., depression, anxiety, positive affect).

Aim 2: To explore the effects of PARK on biological age as defined by DNA methylation (DNAm) GrimAge and electrocardiogram-age (ECG-age), as well as physiological well-being in adults (e.g., cardiovascular, endocrine, musculoskeletal functioning, etc.).

What is being tested

• Positive Emotion Skills Intervention (behavioral)

Sponsor: Northwestern University · Participants: 80 · Started: Sep 1, 2025

Contact the study team

• Chelsea S Brown · Phone: 312-503-3712

Official record on ClinicalTrials.gov — NCT07334106

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.