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Neuroimaging of Adolescent Cannabis Use Treatment
Neuroimaging of Instrumental Learning Networks in Adolescent Cannabis Use Treatment
Who can join
Ages 14 to 17 · All sexes
Full eligibility criteria
Inclusion Criteria: * 14-17 year old youth * Guardian 18 years or older * Youth is MRI-eligible: No metal implants, prosthetics, orthodontic devices, transdermal medication patches, piercings and/or hair or eyelash extensions that cannot easily be removed, metallic ink tattoos on the neck or face, or claustrophobia, and are not pregnant * Youth must endorse having used cannabis at least once per week over the past month OR youth must have been diagnosed with cannabis use disorder within the past three months Exclusion Criteria: * Youth has a history of Fetal Alcohol Spectrum Disorder, intellectual disorders, pervasive development disorder or autism spectrum disorder, psychotic disorders, history of neurological problems (epilepsy, traumatic brain injury, brain tumor, cerebrovascular disease) by parent/guardian report * Youth or caretaker who is monolingual non-English speaker * Youth who is currently experiencing active psychosis symptoms or suicidal/homicidal ideation or who has been hospitalized within the past 6 months for psychosis or suicidality/homicidality * Youth who is currently undergoing contingency management treatment for cannabis use disorder
About the study
This study is testing whether brain activity related to learning can help predict how well teens respond to a treatment program designed to reduce cannabis use. Teens ages 14-17 will complete a brain scan and then take part in 10 weekly virtual sessions where they report cannabis use and complete drug tests at home. Participants can earn prizes for staying cannabis-free.
What is being tested
- Contingency Management (behavioral)
- Elastic Net Regression (device)
Sponsor: Indiana University · Participants: 80 · Started: Jun 15, 2026
Contact the study team
- Joseph Aloi, MD, PhD · Phone: 317-278-5433
- Katherine LeFevre, BS · Phone: 317-278-5433
Official record on ClinicalTrials.gov — NCT07340554
Locations in the U.S.
| Indiana | Indiana University School of Medicine, Indianapolis |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.