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Minimal Sedation During Knee Replacement Surgery

Minimal Sedation During Total Knee Arthroplasty: A Prospective Randomized Control Trial

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* Primary Total Knee Arthroplasty
* Indicated for Spinal Anesthesia
* 18+ years old
* Participant can independently provide informed consent

Exclusion Criteria:

* Unicompartmental Knee Arthroplasty
* Revision Knee Arthroplasty

About the study

This study will test the use of active noise cancelling headphones with music or a movie during knee replacement surgery. Feedback from the surgical team and from patients regarding the headset system will be gathered to see if using it can reduce the amount of sedation needed during knee replacement procedures that use localized anesthesia.

What is being tested

• Active Noise Cancelling Headset System (device)

Sponsor: Mayo Clinic · Participants: 200 · Started: Dec 11, 2025

Contact the study team

• Gabriel D Schouten · Phone: 507-266-5895
• Matthew Hoplin · Phone: 507-284-1003

Official record on ClinicalTrials.gov — NCT07371390

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.