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Open-label Placebo for Pain Management in Adolescents and Young Adults Undergoing Bernese Periacetabular Osteotomy

Conditioning, Open-label Placebo for Pain Management in Adolescents and Young Adults Undergoing Bernese Periacetabular Osteotomy (PAO)

Who can join

Ages 13 to 40 · All sexes

Inclusion Criteria:

* Aged 13 to 40 years old, and
* Undergo primary Bernese Periacetabular osteotomy (PAO) for symptomatic developmental dysplasia of the hip (DDH), and
* Opioid-naïve prior to operation, and
* Capable of completing study procedures, including daily pain and medication diaries as well as weekly questionnaires.

Exclusion Criteria:

* Undergoing PAO revision or any concurrent major surgical procedure
* History of opioid use, substance use disorders, or alcohol abuse
* Those with cognitive or physical impairments that would interfere with providing their own consent and the completion of study-related tasks
* Pregnant individuals or those planning to become pregnant during the study period

About the study

In this randomized controlled trial, 64 participants undergoing PAO at UCSF will be enrolled and randomized to receive either COLP plus treatment as usual (TAU) or TAU alone. Patients in the COLP arm will receive placebo pills alongside prescribed opioids and at scheduled intervals, beginning on postoperative day one. Weekly follow-up will be conducted for six weeks postoperatively via remote surveys and video visits.

What is being tested

• Open-Label Placebo (other)
• Treatment as usual (other)

Sponsor: University of California, San Francisco · Participants: 64 · Started: 2026-12

Contact the study team

• Tripta Rughwani · Phone: 415-353-4701

Official record on ClinicalTrials.gov — NCT07373210

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.