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Low Versus High Load Training and Parkinson's Disease

Comparison of Changes in Neuromuscular and Functional Performance Due to Resistance Training With Low-Load or High-Load in Persons With Parkinson's Disease.

Who can join

Ages 50 to 85 · All sexes

Inclusion Criteria:

* Parkinson's Disease Hoehn \& Yahr Stages 1-3
* Able to walk 50m unassisted
* Able to understand and communicate in English
* A Montreal Cognitive Assessment (MoCA) score above 18

Exclusion Criteria:

* Uncontrolled cardiovascular or other neuromuscular disease that prevent participation in a training program
* Any systemic inflammatory or autoimmune conditions such as rheumatoid arthritis, or other serious concomitant medical illness
* Unresolved injury or surgery to the upper or lower limbs that prevents weight training.

About the study

This study will compare the effects of high-load resistance training to low-load resistance training, on measures of muscle strength and power and tests of daily performance in older adults with Parkinson's disease.

What is being tested

• Low-Load Resistance Training (behavioral)
• High-Load Resistance Training (behavioral)

Sponsor: University of Miami · Participants: 60 · Started: Jan 30, 2026

Contact the study team

• Ethan J Elway, MS · Phone: 3052844173
• Joseph F. Signorile, PhD · Phone: 3052843105

Official record on ClinicalTrials.gov — NCT07378813

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.