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Molecular Indicators of Systematic Fitness

Who can join

Ages 18 and older · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* Be ≥18 years old
* Be able to understand and provide informed consent (English; additional languages may be added via amendment with translated materials)
* Be willing to complete VO₂max testing, blood draw, and questionnaires.
* Be able to safely perform maximal/symptom-limited exercise testing as determined by: PAR-Q+ screening and investigator review (included as an attachment) and resting vitals screening (heart rate)

Exclusion Criteria:

* Conditions that, in the investigator's judgment, or a medical doctor, makes maximal exercise testing unsafe (e.g., unstable cardiovascular symptoms)
* Contraindications or unwillingness to undergo venipuncture
* Acute illness (fever, significant respiratory illness) at the time of testing
* Failure to comply with procedures.

About the study

The goal of this study is to characterize associations between cardiorespiratory fitness, as measured by VO₂max/VO₂peak, and blood-based molecular measurements in adults. This is an observational study where research staff measures VO₂max/VO₂peak and collects fasted, resting blood samples on the same day. The main questions it aims to answer are:

1. Can a multi-analyte blood panel accurately predict directly measured VO₂max/VO₂peak? 2. How do these blood-based features vary across age, sex, and self-reported or documented physical activity profiles? 3. Are the predictor analytes able to capture changes in VO₂max/VO₂peak caused by a self-directed intervention (e.g., training for a marathon)? 4. What is the analytic reliability of the predictor biomarkers?

What is being tested

• There is no intervention. (other)

Sponsor: VO Health, Inc. · Participants: 250 · Started: Jan 5, 2026

Contact the study team

• Brooks P Leitner, MD, PhD · Phone: 443-474-7206

Official record on ClinicalTrials.gov — NCT07393841

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.