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Reduction of Bacterial Seeding in Total Shoulder Arthroplasty

Reduction of Bacterial Seeding in Total Shoulder Arthroplasty: Prontosan Antimicrobial Gel Incision Preparation Versus No Preparation in Male Patients

Who can join

Ages 18 and older · Men

Inclusion Criteria:

* Adult male 18 years of age or older undergoing elective primary total shoulder arthroplasty, including both anatomic and reverse total shoulder arthroplasty, for indications including massive rotator cuffs, rotator cuff arthropathy, glenohumeral osteoarthritis, and acute fractures.

Exclusion Criteria:

* Any revision shoulder arthroplasty procedure or other shoulder surgery that is not a primary shoulder arthroplasty.
* Patients with allergy to active ingredients in Prontosan gel
* Patient is unable to consent for themselves
* Patient is non-English speaking
* Females

About the study

The purpose of this study is to compare the growth of intra-operative tissue cultures of Cutibacterium Acnes after primary shoulder replacement when using a no-prep control group versus Prontosan wound gel applied to the skin layer after the skin incision has been made.

What is being tested

• Prontosan Wound Gel (device)

Sponsor: St. Louis University · Participants: 60 · Started: Feb 23, 2026

Contact the study team

• Randall Otto, MD · Phone: 314-617-2970
• Allison Gruender, RN, MSN · Phone: 314-617-3406

Official record on ClinicalTrials.gov — NCT07406893

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.